Matteo Mecacci served as a member of the Italian Chamber of Deputies (on its Foreign Affairs Committee) as well as an elected official of the Organization for Security and Co-operation in Europe (OSCE) Parliamentary Assembly. Prior to taking up the Presidency at International Campaign for Tibet, he supervised elections in Georgia as the Head of Mission for the OSCE/Office for Democratic Institutions and Human Rights (ODIHR) for the Presidential Elections in Georgia.
Mecacci was elected Chairperson of the Italian Parliamentary Intergroup for Tibet after being voted in as Deputy for the Radical Party on the Democratic Party lists at the 2008 general elections. In November 2009, he organized the 5th World Parliamentarians Convention on Tibet in Rome, which hosted the Dalai Lama and established an International Network of Parliamentarians on Tibet (INPaT). He became Co-Chair of the network in June 2010. He was a member of the Tibetan Election Observation Mission in March, 2011 when the Tibetan community in exile undertook elections for the Central Tibetan Administration leadership.
Mecacci served as the representative of the Transnational Radical Party and No Peace Without Justice at the United Nations in New York from 2000 to 2008. He was part of a coalition of international NGOs advocating the reform of the United Nations—in particular the United Nations Commission on Human Rights—and he was one of the promoters of the International Steering Committee of the Community of Democracies. He studied international law at the University of Firenze.